General description

A cell-permeable Monastrol (Cat. No. 475879) analog with much enhanced potency and selectivity (over 8 other kinesins) in inhibiting mitotic kinesin Eg5-ATPase activity (IC₅₀ = 1.17 vs. 20.73 µM for VS-83 and Monastrol, respectively) and in inducing monoasters formation (EC₅₀ = 7.27 vs. 58.74 µM for BSC-1 cells treated with VS-83 and Monastrol, respectively). Shown to exhibit ≥10-fold antiproliferative activity than Monastrol against U-87 MG, U-118 MG, and U-373 MG glioblastoma cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Muller, C., et al. 2007. Cancer Chemother. Pharmacol.59, 157.Santamaria, A., et al. 2007. Mol. Biol. Cell18, 4024.Sarli, V., et al. 2005. ChemBioChem6, 2005.

Packaging

5 mg in Glass bottle

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Regulatory Review (Z)